• Navigating Drug-Induced Advers...

Treffer: Navigating Drug-Induced Adversities: A Python-Based Console Application for Causality Assessment Using the Naranjo Algorithm.

Title:
Navigating Drug-Induced Adversities: A Python-Based Console Application for Causality Assessment Using the Naranjo Algorithm.
Authors:
Kumar MB; Pharmacology, Varun Arjun Medical College & Rohilkhand Hospital, Banthra, IND., Shaifali I; Pharmacology, Rohilkhand Medical College and Hospital, Bareilly, IND., Gairola B; Pharmacology, Varun Arjun Medical College & Rohilkhand Hospital, Banthra, IND.
Source:
Cureus [Cureus] 2023 Dec 04; Vol. 15 (12), pp. e49911. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2023).
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
Imprint Name(s):
Original Publication: Palo Alto, CA : Cureus, Inc.
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Contributed Indexing:
Keywords: adverse drug reactions (adrs); causality assessment; clinical decision tool; naranjo algorithm; python-based console application
Entry Date(s):
Date Created: 20240104 Latest Revision: 20240105
Update Code:
20250114
PubMed Central ID:
PMC10763692
DOI:
10.7759/cureus.49911
PMID:
38174193
Database:
MEDLINE

Weitere Informationen

The timely and accurate adverse drug reactions (ADR) assessment is vital for effective patient management and healthcare delivery. The Naranjo Algorithm is a widely recognized tool for determining the probability that a drug induces a given ADR. However, the process can be time-consuming and susceptible to human error. This study introduces a Python-based console application (Python Software Foundation, Wilmington, Delaware, United States) designed to automate the Naranjo Algorithm for ADR causality assessment. The application was developed using Python 3.11.4 on a Windows 11 system (Microsoft Corporation, Redmond, Washington, United States) and compiled in Notepad (Microsoft Corporation), a basic text editor, highlighting its accessibility and ease of use in various settings. User input is solicited for each question in the Naranjo Algorithm, validated for acceptable entries, and subsequently scored. The final score categorizes the reaction into Doubtful, Possible, Probable, or Definite ADR, facilitating rapid clinical decision-making. Preliminary validation shows promising reliability and effectiveness, making it a valuable asset in research and clinical settings for assessment.
(Copyright © 2023, Kumar et al.)

The authors have declared that no competing interests exist.