Result: Development and validation of a Python 3 based software to calculate mean platelet survival time by multiple-hit method.

Title:
Development and validation of a Python 3 based software to calculate mean platelet survival time by multiple-hit method.
Authors:
Miñana Olmo E; Unidad de Radiofarmacia, Hospital General Universitario Santa Lucía, Cartagena, Spain., Chivato Martín-Falquina T
Source:
Nuclear medicine communications [Nucl Med Commun] 2023 Dec 01; Vol. 44 (12), pp. 1189-1190. Date of Electronic Publication: 2023 Sep 15.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8201017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5628 (Electronic) Linking ISSN: 01433636 NLM ISO Abbreviation: Nucl Med Commun Subsets: MEDLINE
Imprint Name(s):
Publication: London : Lippincott Williams & Wilkins
Original Publication: London : Chapman and Hall in association with the British Nuclear Medicine Society, c1980-
MeSH Terms:
Software*, Humans ; Kinetics
References:
Roca M, Muñiz-Diaz E, Mora J, Romero-Zayas I, Ramón O, Roig I, et al. The scintigraphic index spleen/liver at 30 minutes predicts the success of splenectomy in persistent and chronic primary immune thrombocytopenia. Am J Hematol 2011; 86:909–913.
International Committee for Standardization in Hematology. Panel on diagnostic applications of radionuclides. Recommended method for indium-111 platelet survival studies. J Nucl Med 1988; 29:564–566.
Murphy EA, Francis ME. The estimation of blood platelet survival. II. The multiple hit model. Thromb Diath Haemorrh 1971; 25:53–80.
Lötter MG, Rabe WL, Van Zyl JM, Heyns AD, Wessels P, Kotzé HF, et al. A computer program in compiled BASIC for the IBM personal computer to calculate the mean platelet survival time with the multiple-hit and weighted mean methods. Comput Biol Med 1988; 18:305–315.
Entry Date(s):
Date Created: 20230915 Date Completed: 20231109 Latest Revision: 20250807
Update Code:
20250808
DOI:
10.1097/MNM.0000000000001766
PMID:
37711080
Database:
MEDLINE

Further Information

Platelet kinetic parameters predict the efficiency of splenectomy in patients with immune thrombocytopenia. The multiple hit model is recommended to calculate the mean platelet survival time. This method involves complex formulae and iterative calculations that need specialized software, but currently available programs present some drawbacks. A new optimized solution is proposed. A Python 3 based computer program was developed in order to perform the multiple-hit model calculations. Validation was done by comparing its results to two additional programs, one using the Microsoft Excel solver add-in and the other fitting the curve by brute force. There was no difference in the results obtained by the three programs. The brute force program however took much longer times to achieve the results. The new program proved to be a fast, robust solution to determine the multiple-hit parameters needed to assess platelet kinetics.
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